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Review
. 2006 Sep;65(9):1121-3.
doi: 10.1136/ard.2006.051789.

Methotrexate pharmacogenomics

J M Kremer  1
Affiliations
Review

Methotrexate pharmacogenomics

J M Kremer. Ann Rheum Dis. 2006 Sep.

Abstract

Observations of clinical effects of methotrexate will help in patient‐management decisions

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Conflict of interest statement

Competing interests: None declared.

Comment on

References

    1. Kremer J M. Toward a better understanding of methotrexate [review]. Arthritis Rheum 2004501370–1382. - PubMed
    1. Hughes L B, Beasley M T, Patel H, Tiwari H K, Morgan S L, Baggott J E.et al Racial/ethnic differences in allele frequencies of single nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis 2006 - PMC - PubMed
    1. Kim R J, Becker R C. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta‐analysis of published studies. Am Heart J 2003146948–957. - PubMed
    1. Gos M, Jr, Szpecht‐potocka A. Genetic basis of neural tube defects. II. Genes correlated with folate and methionine metabolism. J Appl Genet 200243511–524. - PubMed
    1. Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. Am J Pharmacogenomics 2001189–201. - PubMed

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