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. 2006 Oct;42(15):2492-8.
doi: 10.1016/j.ejca.2006.05.027.

Numerous high-risk epithelial lesions in familial breast cancer

N Hoogerbrugge  1 , P Bult, J J Bonenkamp, M J L Ligtenberg, L A Kiemeney, J A de Hullu, C Boetes, M F Niermeijer, H G Brunner
Affiliations

Numerous high-risk epithelial lesions in familial breast cancer

N Hoogerbrugge et al. Eur J Cancer. 2006 Oct.

Abstract

Purpose: To assess the occurrence of high-risk epithelial lesions in women of breast cancer families with and without a BRCA mutation.

Patients and methods: Prospective study of women at very high risk of breast cancer undergoing prophylactic mastectomy (68 BRCA1 mutation carriers, 14 BRCA2 mutation carriers and 24 non-BRCA mutation carriers).

Results: The prevalence of high-risk lesions is equal in women with a BRCA1 or a BRCA2 mutation, but is higher in non-BRCA mutation carriers: all lesions 43% versus 71% (p=0.02), atypical lobular hyperplasia 26% versus 67% (p=0.001), atypical ductal hyperplasia 17% versus 42% (p=0.01), lobular carcinoma-in situ 15% versus 29% (p=0.10) and ductal carcinoma-in situ 9% versus 17% (p=0.25). The presence of high-risk lesions is related to absence of a BRCA mutation and to age over 40 years.

Conclusion: Women with an autosomal dominant family history for breast cancer, with and without a BRCA mutation are prone to develop high-risk epithelial lesions, especially over 40 years.

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