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Comment
. 2006 Aug 17;51(4):393-5.
doi: 10.1016/j.neuron.2006.08.003.

Not too excited? Thank your endocannabinoids

Bradley E Alger  1
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Not too excited? Thank your endocannabinoids

Bradley E Alger. Neuron. .
Free article

Abstract

Endocannabinoids can mediate neuroprotection, but it is not known how. In this issue of Neuron, Monory et al. use mutant mice and localized viral targeting to produce conditional knockouts of the cannabinoid CB1 receptor. They show that protection against kainic acid-induced seizures and cell death is conferred by CB1Rs on hippocampal glutamatergic nerve terminals.

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  • The endocannabinoid system controls key epileptogenic circuits in the hippocampus.
    Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave KA, During M, Klugmann M, Wölfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B. Monory K, et al. Neuron. 2006 Aug 17;51(4):455-66. doi: 10.1016/j.neuron.2006.07.006. Neuron. 2006. PMID: 16908411 Free PMC article.