Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Apr;10(4):1769-72.
doi: 10.1128/mcb.10.4.1769-1772.1990.

mRNAs that mature through trans-splicing in Caenorhabditis elegans have a trimethylguanosine cap at their 5' termini

K Van Doren  1 , D Hirsh
Affiliations

mRNAs that mature through trans-splicing in Caenorhabditis elegans have a trimethylguanosine cap at their 5' termini

K Van Doren et al. Mol Cell Biol. 1990 Apr.

Abstract

Approximately 10% of the mRNAs in the nematode Caenorhabditis elegans mature through a trans-splicing mechanism that involves the transfer of a 22-nucleotide spliced leader to the 5' end of the pre-mRNA. The spliced leader RNA exists as a small nuclear ribonucleoprotein particle and has the trimethylguanosine cap that is characteristic of eucaryotic small nuclear RNAs. We found that the trimethylguanosine cap present on the spliced leader RNA was transferred to the pre-mRNA during the trans-splicing reaction. Thereafter, the trimethylguanosine cap was maintained on the mature mRNA. This is the first example of eucaryotic cellular mRNAs possessing a trimethylguanosine cap structure.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5187-91 - PubMed
    1. Nature. 1976 Nov 11;264(5582):190-1 - PubMed
    1. Genes Dev. 1988 Oct;2(10):1277-83 - PubMed
    1. Cell. 1984 Oct;38(3):731-6 - PubMed
    1. Nucleic Acids Res. 1987 Feb 25;15(4):1387-99 - PubMed

Publication types

LinkOut - more resources