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Case Reports
. 2006 Aug;27(7):1483-5.

CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland

S P Sheedy  1 , K M Welker, D R DeLone, J R Gilbertson
Affiliations
Case Reports

CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland

S P Sheedy et al. AJNR Am J Neuroradiol. 2006 Aug.

Abstract

Pleomorphic adenomas (PAs), also known as benign mixed tumors, are common tumors of the parotid gland. These tumors occasionally undergo malignant transformation, with potentially devastating consequences. This case report presents the clinical and radiographic features of a rare case of biopsy proved brain and spinal cord metastases arising from carcinoma ex PA of the parotid gland.

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Figures

Fig. 1.
Fig. 1.
A, Axial image from noncontrast CT examination of the head demonstrates a heterogeneous mass involving the superficial right parotid gland (arrow). B, Photomicrograph of tumor in A demonstrates nests of basophilic tumor cells arising from a PA. (H&E stain × 100).
Fig. 2.
Fig. 2.
A, Postgadolinium T1-weighted MR images demonstrate multiple enhancing nodular lesions throughout both cerebral and cerebellar hemispheres, several of which have an unusual lamellated pattern of enhancement. B, T2-weighted and FLAIR MR images with paired postgadolinium T1-weighted images demonstrate significant vasogenic edema associated with several of these lesions.
Fig. 3.
Fig. 3.
MR imaging of the cervical spine. T2-weighted image demonstrates patchy increased T2 signal intensity in the cervical cord (A). Postgadolinium T1-weighted image demonstrates an enhancing intramedullary nodular lesion at the T1 level (B, arrow).
Fig. 4.
Fig. 4.
Photomicrograph of brain biopsy specimen shows metastatic grade (4/4) carcinoma (left) invading normal brain parenchyma (right) (H&E stain × 100).
See this image and copyright information in PMC

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