Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Aug 22;103(34):12659-60.
doi: 10.1073/pnas.0605675103. Epub 2006 Aug 14.

Single gene control of a complex phenotype hangs in the balance

Christina M Hull  1
Affiliations
Comment

Single gene control of a complex phenotype hangs in the balance

Christina M Hull. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: No conflicts declared.

Figures

Fig. 1.
Fig. 1.
Integrated model of WOR1-controlled switching. In white a or α cells there is little Wor1 protein (blue circles) produced, causing the cells to remain in the white phase. In a rare, random event, the protein levels increase, activate more WOR1 expression (big green arrows) in an autoregulatory feedback loop, and cause a switch to the opaque phase (approximately once per 10,000 generations). Subsequent generations are primarily in the opaque phase because enough protein is inherited to sustain high-level expression of WOR1. However, rare, random events in which the Wor1 protein levels drop below a critical threshold lead to low levels of WOR1 expression (small gray arrows) and the production of white cells in the population. Changing concentrations of Wor1 tip the balance between two states in a bistable mechanism of control. Adapted from Zordan et al. (2).
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

References

    1. Struhl K. Annu. Rev. Genet. 1995;29:651–674. - PubMed
    1. Zordan R. E., Galgoczy D. J., Johnson A. D. Proc. Natl. Acad. Sci. USA. 2006;103:12807–12812. - PMC - PubMed
    1. Huang G., Wang H., Chou S., Nie X., Chen J., Liu H. Proc. Natl. Acad. Sci. USA. 2006;103:12813–12818. - PMC - PubMed
    1. Bennett R. J., Johnson A. D. Annu. Rev. Microbiol. 2005;59:233–255. - PubMed
    1. Slutsky B., Staebell M., Anderson J., Risen L., Pfaller M., Soll D. R. J. Bacteriol. 1987;169:189–197. - PMC - PubMed

LinkOut - more resources