[Inhibition of ethanol exidation on prolonged fasting in man: reversibility on fructose infusion(author's transl)]
- PMID: 169115
[Inhibition of ethanol exidation on prolonged fasting in man: reversibility on fructose infusion(author's transl)]
Abstract
Fasting for over 36 hours was found to inhibit ethanol metabolism in healthy volunteers by 43% (P less than 0.01) compared with values obtained after 12 hours' fasting. Ethanol oxidation was not inhibited by prolonged fasting when it was stimulated by intravenous fructose. The explanation for this effect is thought to lie in the inhibition of alcohol oxidation mainly by limiting the rate of NADH-reoxidation in the liver.
Similar articles
-
Alteration of hepatic ethanol metabolism in CCL4-intoxicated rats: analysis using isolated liver perfusion system.Subst Alcohol Actions Misuse. 1982;3(3):163-75. Subst Alcohol Actions Misuse. 1982. PMID: 6763360
-
Oral fructose-induced changes in blood ethanol oxidokinetic data among healthy Nigerians.Southeast Asian J Trop Med Public Health. 2004 Jun;35(2):476-80. Southeast Asian J Trop Med Public Health. 2004. PMID: 15691159
-
The effect of fructose on alcohol metabolism and on the [lactate]/[pyruvate] ratio in man.Alcohol Alcohol. 1991;26(1):53-9. Alcohol Alcohol. 1991. PMID: 1854373
-
Ethanol metabolism.Int Rev Physiol. 1980;21:275-315. Int Rev Physiol. 1980. PMID: 6993397 Review. No abstract available.
-
Rate-limiting steps in ethanol metabolism and approaches to changing these rates biochemically.Adv Exp Med Biol. 1975;56:77-109. doi: 10.1007/978-1-4684-7529-6_4. Adv Exp Med Biol. 1975. PMID: 167557 Review.
Cited by
-
The metabolism of alcohol: physiological and pathophysiological aspects.J R Coll Physicians Lond. 1978 Jan;12(2):122-35. J R Coll Physicians Lond. 1978. PMID: 340682 Free PMC article. Review. No abstract available.
-
Alcohol metabolism in man: effect of intravenous fructose infusion on blood ethanol elimination rate following stimulation by phenobarbital treatment or chronic alcohol consumption.Klin Wochenschr. 1979 Feb 1;57(3):125-30. doi: 10.1007/BF01476052. Klin Wochenschr. 1979. PMID: 439778
-
The effects of starving and refeeding on the intra-acinar distribution pattern of alcohol-dehydrogenase activity in rat liver.Histochemistry. 1987;86(3):275-9. doi: 10.1007/BF00490258. Histochemistry. 1987. PMID: 3570876