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Randomized Controlled Trial
. 2006 Aug;23(8):920-3.
doi: 10.1111/j.1464-5491.2006.01921.x.

The effects of calcitriol and nicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI)

D Pitocco  1 , A Crinò, E Di Stasio, S Manfrini, C Guglielmi, S Spera, G Beretta Anguissola, N Visalli, C Suraci, M C Matteoli, I P Patera, M G Cavallo, C Bizzarri, P Pozzilli; IMDIAB Group
Affiliations
Randomized Controlled Trial

The effects of calcitriol and nicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI)

D Pitocco et al. Diabet Med. 2006 Aug.

Abstract

Background: A number of recent studies underline the importance of vitamin D in the pathogenesis of Type 1 diabetes (T1D).

Aims: The aim of this study was to investigate whether supplementation with the active form of vitamin D (calcitriol) in subjects with recent-onset T1D protects residual pancreatic beta-cell function and improves glycaemic control (HbA(1c) and insulin requirement).

Methods: In this open-label randomized trial, 70 subjects with recent-onset T1D, mean age 13.6 years +/- 7.6 sd were randomized to calcitriol (0.25 microg on alternate days) or nicotinamide (25 mg/kg daily) and followed up for 1 year. Intensive insulin therapy was implemented with three daily injections of regular insulin + NPH insulin at bedtime.

Results: No significant differences were observed between calcitriol and nicotinamide groups in respect of baseline/stimulated C-peptide or HbA1c 1 year after diagnosis, but the insulin dose at 3 and 6 months was significantly reduced in the calcitriol group.

Conclusions: At the dosage used, calcitriol has a modest effect on residual pancreatic beta-cell function and only temporarily reduces the insulin dose.

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