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. 2006 Sep 15;43(6):783-6.
doi: 10.1086/507097. Epub 2006 Aug 15.

Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration

David W Haas  1 , John A Bartlett, Janet W Andersen, Ian Sanne, Grant R Wilkinson, John Hinkle, Franck Rousseau, Christiana D Ingram, Audrey Shaw, Michael M Lederman, Richard B Kim; Adult AIDS Clinical Trials Group
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Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration

David W Haas et al. Clin Infect Dis. .

Abstract

Associations have been reported between an MDR1 variant and responses to nonnucleoside reverse-transcriptase inhibitors. We explored associations between MDR1, CYP2B6, and CYP3A polymorphisms and nevirapine hepatotoxicity. Among participants in a randomized study in South Africa (FTC-302), MDR1 3435C-->T was significantly associated with decreased risk of hepatotoxicity (risk ratio, 0.30; P=.016).

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