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. 2006 Jun;21(2):103-8.
doi: 10.3904/kjim.2006.21.2.103.

Efficacy of irbesartan on left ventricular mass and arterial stiffness in hypertensive patients

Chang Gyu Park  1 , Jeong Cheon Ahn, Soon Jun Hong, Eung Joo Kim, Seung Jin Lee, Seong Mi Park, Hong Seog Seo, Dong Joo Oh
Affiliations

Efficacy of irbesartan on left ventricular mass and arterial stiffness in hypertensive patients

Chang Gyu Park et al. Korean J Intern Med. 2006 Jun.

Erratum in

  • Korean J Intern Med. 2010 Mar;25(1):118. Park, Sung Mi [corrected to Park, Seong Mi]

Abstract

Background: Increased aortic stiffness measured by pulse wave velocity (PWV) and left ventricular hypertrophy (LVH) are independent risk factors of cardiovascular events in hypertensive patients. We have conducted a prospective study to examine the effects of the angiotensin II receptor antagonist (irbesartan) on PWV and LVH in hypertensive patients.

Methods: A total of 52 untreated hypertensive patients (age: 53.3 +/- 8.0 yrs) were enrolled; they had no evidence of associated cardiovascular complications. Blood pressure, heart rate, aortic PWV and left ventricular mass index (LVMI) by 2-D echocardiography were measured at baseline and after irbesartan treatment (150 mg or 300 mg/day) at 12 weeks and 24 weeks.

Results: Blood pressure was significantly decreased after 12 weeks and 24 weeks of treatment compared to baseline (SBP: 134.6 +/- 13.3 mmHg, 134.0 +/- 11.0 mmHg vs 163.7 +/- 13.8 mmHg p < 0.001, DBP: 86.0 +/- 10 mmHg, 83.07 mmHg vs 102.4 +/- 9.6 mmHg p < 0.001, respectively) without significant change in heart rate. LVMI decreased at 12 weeks and at 24 weeks after treatment compared to baseline (from 145.5 +/- 35.1 g/m2 at baseline to 137.5 +/- 35.4 g/m2 at 12 weeks, p = 0.017 and 135.3 +/- 35.4 g/m2 at 24 weeks, p = 0.008). Aortic PWV was decreased after irbesartan treatment at 12 weeks (from 9.6 +/- 2.8 m/sec to 8.7 +/- 3.1 m/sec at 12 weeks, p = 0.064) and at 24 weeks (from 9.6 +/- 2.9 m/sec to 7.7 +/- 2.1 m/sec at 24 weeks, p = 0.007).

Conclusions: Long-term treatment with irbesartan may reduce arterial stiffness and regression of LVH in hypertensive patients. The pleiotropic effects of irbesartan, further decreasing PWV without change of BP between 12 and 24 weeks of treatment, may have favorable vascular effects on arterial stiffness and LVH.

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Figures

Figure 1
Figure 1
Measurement of pulse wave velocity by the foot-to-foot method. T1 and T2 are the time intervals of the appearance of a Doppler wave just distal to the left subclavian artery of the descending aorta, and at the right femoral artery from the QRS wave of the ECG measured by cardiac ultrasonography.
Figure 2
Figure 2
Change of LVMI after irbesartan treatment. NS, not significant.
Figure 3
Figure 3
Change of PWV after irbesartan treatment. NS, not significant.
See this image and copyright information in PMC

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