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Randomized Controlled Trial
. 2006 Oct 10;67(7):1251-3.
doi: 10.1212/01.wnl.0000233831.87781.a9. Epub 2006 Aug 16.

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients

J M Leung  1 , L P Sands, M Rico, K L Petersen, M C Rowbotham, J B Dahl, C Ames, D Chou, P Weinstein
Affiliations
Randomized Controlled Trial

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients

J M Leung et al. Neurology. .

Abstract

In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.

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