doi: 10.3233/jad-2006-9s343.
Genetic complexity of Alzheimer's disease: successes and challenges
Affiliations
- PMID: 16914876
- DOI: 10.3233/jad-2006-9s343
Item in Clipboard
Genetic complexity of Alzheimer's disease: successes and challenges
J Alzheimers Dis.
2006.
Abstract
About 1% of Alzheimer's Disease (AD) cases have an early-onset autosomal dominant familial form of the disease, genetic analyses of which have found three causal genes: amyloid beta-protein precursor (AbetaPP), presenilin 1 (PS1) and presenilin 2 (PS2). The APOE gene is the only robustly replicated risk factor for the common form of AD with onset after 65 years of age. In at least half of the AD cases, there is no known cause of the disease. Here we provide an overview on known AD-linked genes and discuss the strategies of searching for novel AD genetic risk factors.
Similar articles
-
Molecular genetics of Alzheimer's disease.Geriatrics. 1997 Sep;52 Suppl 2:S9-12. Geriatrics. 1997. PMID: 9307578 Review.
-
Candidate gene association studies in sporadic Alzheimer's disease.Dement Geriatr Cogn Disord. 2002;14(1):41-54. doi: 10.1159/000058332. Dement Geriatr Cogn Disord. 2002. PMID: 12053131 Review.
-
Alzheimer's disease: genotypes, phenotypes, and treatments.Science. 1997 Jan 31;275(5300):630-1. doi: 10.1126/science.275.5300.630. Science. 1997. PMID: 9019820 Review. No abstract available.
-
Frequency of mutations in the presenilin and amyloid precursor protein genes in early-onset Alzheimer disease in Spain.Arch Neurol. 2002 Nov;59(11):1759-63. doi: 10.1001/archneur.59.11.1759. Arch Neurol. 2002. PMID: 12433263
-
[Advances in molecular biology and clinical study of amyloid precursor protein for Alzheimer's disease].Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Apr;26(2):201-9. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004. PMID: 15171563 Review. Chinese.
Cited by
-
Mechanisms of Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope.Oxid Med Cell Longev. 2022 May 14;2022:4759963. doi: 10.1155/2022/4759963. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35607703 Free PMC article. Review.
-
A common molecular and cellular pathway in developing Alzheimer and cancer.Biochem Biophys Rep. 2023 Dec 26;37:101625. doi: 10.1016/j.bbrep.2023.101625. eCollection 2024 Mar. Biochem Biophys Rep. 2023. PMID: 38225990 Free PMC article. Review.
-
Growth hormone/insulin-like growth factor I axis in neurodegenerative diseases.J Endocrinol Invest. 2010 Sep;33(8):587-91. doi: 10.1007/BF03346653. J Endocrinol Invest. 2010. PMID: 20930497 Review.
-
Alzheimer's Disease and Cancer: When Two Monsters Cannot Be Together.Front Neurosci. 2019 Mar 1;13:155. doi: 10.3389/fnins.2019.00155. eCollection 2019. Front Neurosci. 2019. PMID: 30881282 Free PMC article.
-
mTOR-dependent signalling in Alzheimer's disease.J Cell Mol Med. 2008 Dec;12(6B):2525-32. doi: 10.1111/j.1582-4934.2008.00509.x. J Cell Mol Med. 2008. PMID: 19210753 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
