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. 2007 Mar;196(1):31-9.
doi: 10.1007/s00430-006-0026-x. Epub 2006 Aug 18.

Murine polyomavirus-like particles induce maturation of bone marrow-derived dendritic cells and proliferation of T cells

Thomas Bickert  1 , Gisela Wohlleben, Marc Brinkman, Claudia M Trujillo-Vargas, Claus Ruehland, Christian O A Reiser, Juergen Hess, Klaus J Erb
Affiliations

Murine polyomavirus-like particles induce maturation of bone marrow-derived dendritic cells and proliferation of T cells

Thomas Bickert et al. Med Microbiol Immunol. 2007 Mar.

Abstract

We analysed the effects of murine polyomavirus-like particles (PLPs) on bone marrow-derived dendritic cells (BMDCs) and T cells in vitro. BMDCs activated with PLPs up-regulated CD40, CD80, CD86 and major histocompatibility complex (MHC) class II surface markers and produced proinflammatory cytokines. Chimeric PLPs [expressing the ovalbumin (OVA)-peptides OVA(257-264) or OVA(323-339)], but not wildtype PLPs, activated OVA-specific CD8 T cells and OVA-specific CD4 T cells, respectively, indicating both MHC class I and II presentation of the peptides by antigen-presenting cells. Our results suggest that PLPs may be used as vaccine adjuvants priming dendritic cells to induce potent T cell responses.

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