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Review
. 2006;6(14):1465-71.
doi: 10.2174/156802606777951091.

Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic

Terrence R Burke Jr  1
Affiliations
Review

Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic

Terrence R Burke Jr. Curr Top Med Chem. 2006.

Abstract

Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes. Among pTyr mimetics reported to date, phosphono(diflouromethyl)phenylalanine (F(2)Pmp) has shown particular utility when dealing with protein-tyrosine phosphatases (PTPs). The current overview presents the development of F(2)Pmp and a summary of approaches toward its synthesis and use.

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