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. 2006 Oct 1;312(16):3108-19.
doi: 10.1016/j.yexcr.2006.06.017. Epub 2006 Jun 21.

A global genomic transcriptional code associated with CNS-expressed genes

Peter J Bailey  1 , Joanna M Klos, Elisabet Andersson, Mattias Karlén, Magdalena Källström, Jasmina Ponjavic, Jonas Muhr, Boris Lenhard, Albin Sandelin, Johan Ericson
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A global genomic transcriptional code associated with CNS-expressed genes

Peter J Bailey et al. Exp Cell Res. .

Abstract

Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression.

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