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Review
. 2006 Oct;18(5):565-71.
doi: 10.1016/j.ceb.2006.08.008. Epub 2006 Aug 17.

CEACAMs: their role in physiology and pathophysiology

Katharina Kuespert  1 , Stefan Pils, Christof R Hauck
Affiliations
Review

CEACAMs: their role in physiology and pathophysiology

Katharina Kuespert et al. Curr Opin Cell Biol. 2006 Oct.

Abstract

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptors for host-specific viruses and bacteria in mice and humans, respectively, making these proteins an interesting example of pathogen-host co-evolution. Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo.

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Figures

Figure 1
Figure 1
Overview of the human CEACAM family. Schematic representation of major isoforms of the different CEACAM family members are depicted. Further information with regard to alternative splice variants can be found at http://cea.klinikum.uni-muenchen.de/. Species abbreviations: c, cow; d, dog; e, elephant; h, human; m, mouse; o, opossum; r, rat.
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