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Controlled Clinical Trial
. 2006 Jul;13(4):480-7.
doi: 10.1016/j.nuclcard.2006.03.005.

Assessment of global and regional left ventricular function and volumes with 64-slice MSCT: a comparison with 2D echocardiography

Maureen M Henneman  1 , Joanne D Schuijf, J Wouter Jukema, Eduard R Holman, Hildo J Lamb, Albert de Roos, Ernst E van der Wall, Jeroen J Bax
Affiliations
Controlled Clinical Trial

Assessment of global and regional left ventricular function and volumes with 64-slice MSCT: a comparison with 2D echocardiography

Maureen M Henneman et al. J Nucl Cardiol. 2006 Jul.

Abstract

Background: In patients with coronary artery disease (CAD), LV function and volumes are important parameters for long-term prognosis. Multislice computed tomography (MSCT) allows noninvasive assessment of the coronary arteries, but the accuracy of 64-slice MSCT for the assessment of left ventricular (LV) volumes and function is unknown.

Methods and results: A head-to-head comparison between 64-slice MSCT and 2-dimensional (2D) echocardiography was performed in 40 patients with known or suspected CAD. The LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) were determined and the LV ejection fraction (LVEF) was derived. Regional wall motion was assessed visually using a 17-segment model. A 3-point scoring system was used to assign to each segment a wall motion score: 1 = normokinesia, 2 = hypokinesia, 3 = akinesia or dyskinesia. Two-dimensional echocardiography served as the gold standard. MSCT agreed well with 2D echocardiography for assessment of LVEDV (r = 0.97; p < .0001) and LVESV (r = 0.98; p < .0001). An excellent correlation between MSCT and 2D echocardiography was shown for the evaluation of LVEF (r = 0.91; p < .0001). Agreement for the assessment of regional wall motion was excellent (96%, kappa = 0.82).

Conclusions: An accurate assessment of global and regional LV function and volumes is feasible with 64-slice MSCT.

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