doi: 10.1016/j.bmcl.2006.08.032.
Epub 2006 Aug 21.
Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata
Affiliations
- PMID: 16919944
- DOI: 10.1016/j.bmcl.2006.08.032
Item in Clipboard
Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata
Bioorg Med Chem Lett.
.
Abstract
The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.
Similar articles
-
Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata.Bioorg Med Chem Lett. 2005 Dec 15;15(24):5548-52. doi: 10.1016/j.bmcl.2005.08.099. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203143
-
Prenylated xanthones from the root bark of Cudrania tricuspidata.J Nat Prod. 2007 Jul;70(7):1207-9. doi: 10.1021/np070059k. Epub 2007 Jul 4. J Nat Prod. 2007. PMID: 17608532
-
In vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal.Arch Pharm Res. 2008 Apr;31(4):429-37. doi: 10.1007/s12272-001-1175-8. Epub 2008 May 1. Arch Pharm Res. 2008. PMID: 18449499
-
Bioactive compounds from Cudrania tricuspidata: A natural anticancer source.Crit Rev Food Sci Nutr. 2020;60(3):494-514. doi: 10.1080/10408398.2018.1541866. Epub 2018 Dec 22. Crit Rev Food Sci Nutr. 2020. PMID: 30582344 Review.
-
Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.J Agric Food Chem. 2008 Aug 13;56(15):6185-205. doi: 10.1021/jf8006568. Epub 2008 Jul 2. J Agric Food Chem. 2008. PMID: 18593176 Review.
Cited by
-
Isocudraxanthone K induces growth inhibition and apoptosis in oral cancer cells via hypoxia inducible factor-1α.Biomed Res Int. 2014;2014:934691. doi: 10.1155/2014/934691. Epub 2014 Jul 3. Biomed Res Int. 2014. PMID: 25105148 Free PMC article.
-
Indirect homologous competitive enzyme-linked immunosorbent assay for the detection of a class of glycosylated dihydrochalcones.J Agric Food Chem. 2013 Jul 17;61(28):6964-70. doi: 10.1021/jf401302y. Epub 2013 Jul 2. J Agric Food Chem. 2013. PMID: 23767873 Free PMC article.
-
Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata.Molecules. 2015 Jun 17;20(6):11173-83. doi: 10.3390/molecules200611173. Molecules. 2015. PMID: 26091075 Free PMC article.
-
A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia.Molecules. 2016 Sep 16;21(9):1240. doi: 10.3390/molecules21091240. Molecules. 2016. PMID: 27649130 Free PMC article.
-
Anti-atherosclerosis mechanisms associated with regulation of non-coding RNAs by active monomers of traditional Chinese medicine.Front Pharmacol. 2023 Nov 6;14:1283494. doi: 10.3389/fphar.2023.1283494. eCollection 2023. Front Pharmacol. 2023. PMID: 38026969 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information
Medical
