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. 1975 Sep;14(9):688-9.

Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye

A H Neufeld, M L Sears
  • PMID: 169206

Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye

A H Neufeld et al. Invest Ophthalmol. 1975 Sep.

Abstract

Our previous studies showed that cyclic-AMP increases the outflow facility of the eye of the rabbit. In this investigation, an analogue of cyclic-AMP, the 8-methylthio derivative, perfused into the anterior chamber of the eye of the vervet monkey, increased outflow facility twofold. This observation supports the hypothesis that cyclic-AMP mediates the action of adrenergic agents to reduce intraocular pressure in the primate eye.

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