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Review
. 2006 Aug;3(6):489-93.
doi: 10.1513/pats.200603-065MS.

State of the art. Bronchiolitis in chronic obstructive pulmonary disease

James C Hogg  1
Affiliations
Review

State of the art. Bronchiolitis in chronic obstructive pulmonary disease

James C Hogg. Proc Am Thorac Soc. 2006 Aug.
No abstract available

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Figures

<b>Figure 1.</b>
Figure 1.
(A) A collection of bronchial-associated lymphoid tissue with a lymphoid follicle containing a germinal center (GC) surrounded by a rim of darker staining lymphocytes that extend to the epithelium of both the small airway and alveolar surface. (B) Another follicle where the germinal center stains strongly for B cells. (C) A serial section of the same airway stained for CD-4 cells that scatter around the edge of the follicle and in the airway wall. (D) An airway that has been extensively remodeled by connective tissue deposition in the subepithelial and adventitial compartments of the airway wall. (The arrow points to the smooth muscle that separates the subepithelial from the adventitial compartments; Movats stain.)
<b>Figure 2.</b>
Figure 2.
The relationship between the median value for lumen occlusion by inflammatory exudates containing mucus and the decline in FEV1 in 159 cases where lung function was measured just before lung resection for small peripheral tumor or lung volume resection for advanced tumor. •, Gold 4; ▪, Gold 3; ▵, Gold 2, □, Gold 1; ⋄, Gold 0.
<b>Figure 3.</b>
Figure 3.
The relationship between volume of the airway wall and surface area of the basement membrane (estimated as total wall area divided by basement membrane length) and FEV1 from the same cases shown in Figure 1. These data show that the airway wall tends to thicken as FEV1 declines. •, Gold 4; ▪, Gold 3; ▵, Gold 2, □, Gold 1; ⋄, Gold 0.
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