Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Aug;3(6):489-93.
doi: 10.1513/pats.200603-065MS.

State of the art. Bronchiolitis in chronic obstructive pulmonary disease

James C Hogg  1
Affiliations
Review

State of the art. Bronchiolitis in chronic obstructive pulmonary disease

James C Hogg. Proc Am Thorac Soc. 2006 Aug.
No abstract available

PubMed Disclaimer

Figures

<b>Figure 1.</b>
Figure 1.
(A) A collection of bronchial-associated lymphoid tissue with a lymphoid follicle containing a germinal center (GC) surrounded by a rim of darker staining lymphocytes that extend to the epithelium of both the small airway and alveolar surface. (B) Another follicle where the germinal center stains strongly for B cells. (C) A serial section of the same airway stained for CD-4 cells that scatter around the edge of the follicle and in the airway wall. (D) An airway that has been extensively remodeled by connective tissue deposition in the subepithelial and adventitial compartments of the airway wall. (The arrow points to the smooth muscle that separates the subepithelial from the adventitial compartments; Movats stain.)
<b>Figure 2.</b>
Figure 2.
The relationship between the median value for lumen occlusion by inflammatory exudates containing mucus and the decline in FEV1 in 159 cases where lung function was measured just before lung resection for small peripheral tumor or lung volume resection for advanced tumor. •, Gold 4; ▪, Gold 3; ▵, Gold 2, □, Gold 1; ⋄, Gold 0.
<b>Figure 3.</b>
Figure 3.
The relationship between volume of the airway wall and surface area of the basement membrane (estimated as total wall area divided by basement membrane length) and FEV1 from the same cases shown in Figure 1. These data show that the airway wall tends to thicken as FEV1 declines. •, Gold 4; ▪, Gold 3; ▵, Gold 2, □, Gold 1; ⋄, Gold 0.
See this image and copyright information in PMC

References

    1. Hogg JC, Macklem PT, Thurlbeck WM. Site and nature of airways obstruction in chronic obstructive lung disease. N Engl J Med 1968;278:1355–1360. - PubMed
    1. Van Brabandt H, Cauberghs M, Verbeken E, Moerman P, Lauweryns JM, Van de Woestijne KP. Partitioning of pulmonary impedance in excised human and canine lungs. J Appl Physiol 1983;55:1733–1742. - PubMed
    1. Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol 1992;72:1016–1023. - PubMed
    1. Weibel ER. The morphometry of the human lung. New York: New York Academic Press; 1963.
    1. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645–2653. - PubMed

Publication types

MeSH terms

LinkOut - more resources