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Review
. 2006 Aug;3(6):512-6.
doi: 10.1513/pats.200603-072MS.

State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease

Peter M Henson  1 , Gregory P Cosgrove, R William Vandivier
Affiliations
Review

State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease

Peter M Henson et al. Proc Am Thorac Soc. 2006 Aug.
No abstract available

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Figures

<b>Figure 1.</b>
Figure 1.
Model for the normal response to apoptotic cells in the alveolus compared to an impaired response proposed for chronic obstructive pulmonary disease (COPD). HGF = hepatocyte growth factor; TGF-β = transforming growth factor β; VEGF = vascular endothelial growth factor.
<b>Figure 2.</b>
Figure 2.
Cell proliferation occurs within the alveolar wall of the human lung. Nondiseased human lungs were obtained from donors rejected for lung transplantation and stained for the presence of the proliferation marker Ki67 (arrows).
<b>Figure 3.</b>
Figure 3.
Surfactant protein D (SP-D) regulates removal of apoptotic cells in vivo. Apoptotic human neutrophils were instilled intratracheally into SP-D wild-type, overexpressor (OE), or knockout (KO) mice. Thirty minutes later, lungs were lavaged and alveolar macrophages were assessed for ingestion of apoptotic cells as measured by the phagocytic index. *Significantly different from SP-D KO mice; p ⩽ 0.05; **significantly different from SP-D OE mice; p ⩽ 0.05.
See this image and copyright information in PMC

References

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