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Review
. 2006 Sep 15;194 Suppl 1(Suppl 1):S19-26.
doi: 10.1086/505351.

Interferon and its inducers--a never-ending story: "old" and "new" data in a new perspective

Erik De Clercq  1
Affiliations
Review

Interferon and its inducers--a never-ending story: "old" and "new" data in a new perspective

Erik De Clercq. J Infect Dis. .
No abstract available

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Figures

Figure 1
Figure 1
_Structures of polyacrylic acid, polymethacrylic acid, and pyran copolymer
Figure 2
Figure 2
_Structure of poly(I)·poly(C)
Figure 3
Figure 3
_Structure of thiophosphate analogue of poly r(A-U)
Figure 4
Figure 4
_Modulatory role of double-stranded (ds) RNA (modified from [20])
Figure 5
Figure 5
_Structure of adefovir and adefovir dipivoxil. PMEA, 9-(2-phosphonomethoxyethyl)adenine
Figure 6
Figure 6
_Effect of intron A on the replication of hepatitis C virus (genotype 1b) replicon in Huh-7 cells. Unpublished data (average values for 2 experiments) from Jan Paeshuyse, Erik De Clercq, and Johan Neyts (2004). SI, selectivity index
Figure 7
Figure 7
_Structure of neplanocin A and 3-deazaneplanocin A
Figure 8
Figure 8
_Effect of treatment with interferon-α2b (IFN), pegylated interferon-α2b (PEG-IFN), poly(I)·poly(C) (polyIC), and Ampligen on virus titers (determined by quantitative reverse transcription—polymerase chain reaction) in serum, brain, and spleen at 7 days after infection of SCID mice with the flavivirus Modoc. Pre or post, before or after infection; VC, virus control (data from [47])
Figure 9
Figure 9
_Effect of treatment with interferon-α2b (IFN), pegylated interferon-α2b (PEG-IFN), poly(I)·poly(C) (poly(IC)), and Ampligen on Coxsackie B3 virus—induced myocarditis in C3H/HeNHsd mice (data from [48])
See this image and copyright information in PMC

References

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    1. De Somer, P, Prinzie A, Denys P Jr, Schonne E. Mechanism of action of interferon I. Relationship with viral ribonucleic acid. Virology. 1962;16:63–70. - PubMed
    1. Merigan TC. Interferons of mice and men. N Engl J Med. 1967;276:913–20. - PubMed
    1. Merigan TC. Induction of circulating interferon by synthetic anionic polymers of known composition. Nature. 1967;214:416–7. - PubMed
    1. Merigan TC, Regelson W. Interferon induction in man by a synthetic polyanion of defined composition. N Engl J Med. 1967;277:1283–7. - PubMed

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