Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Apr 30;168(2):537-43.
doi: 10.1016/0006-291x(90)92354-3.

Autocrine effect of endothelin on DNA synthesis in human vascular endothelial cells

Y Takagi  1 , M Fukase, S Takata, H Yoshimi, O Tokunaga, T Fujita
Affiliations

Autocrine effect of endothelin on DNA synthesis in human vascular endothelial cells

Y Takagi et al. Biochem Biophys Res Commun. .

Abstract

To elucidate the role of endogenous endothelin on DNA synthesis in endothelial cells, we have investigated the effects of rabbit anti-ET gamma globulin on DNA synthesis in cultured human vascular endothelial cells. DNA synthesis was markedly inhibited by anti-ET gamma globulin in a concentration dependent manner in the presence of fetal calf serum(FCS) (x5000;34%, x2500;54%, x1000;70%), but not in the absence of FCS. These data suggest that endogenous ET modulates FCS-stimulated DNA synthesis in an autocrine fashion.

PubMed Disclaimer

Publication types

LinkOut - more resources