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. 1975 Sep;123(3):851-4.
doi: 10.1128/jb.123.3.851-854.1975.

pyrR identical to pyrH in Salmonella typhimurium: control of expression of the pyr genes

J Justesen, J Neuhard

pyrR identical to pyrH in Salmonella typhimurium: control of expression of the pyr genes

J Justesen et al. J Bacteriol. 1975 Sep.

Abstract

Mutants of Salmonella typhimurium showing constitutive synthesis of the pyrimidine biosynthetic enzymes coded for by the pyrA-F genes (G. A. O'Donavan and J. C. Gerhart, 1972) have been reinvestigated. The high rate of expression of the pyrB-F genes in these mutants as well as their pyrimidine excretion is shown to be due to mutations in the gene pyrH encoding uridine 5'-monophosphate kinase. Thus, the term pyrR used for these mutants should be replaced by the designation pyrH.

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