When it comes to decisions, myeloid progenitors crave positive feedback
- PMID: 16923384
- DOI: 10.1016/j.cell.2006.08.007
When it comes to decisions, myeloid progenitors crave positive feedback
Abstract
Positive feedback is a ubiquitous feature of networks that establish and maintain cellular decisions. In this issue of Cell, Laslo et al. (2006) demonstrate how a feedback loop comprised of two mutual repressors regulates the differentiation of myeloid progenitors into either macrophages or neutrophils.
Comment on
-
Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.Cell. 2006 Aug 25;126(4):755-66. doi: 10.1016/j.cell.2006.06.052. Cell. 2006. PMID: 16923394
Similar articles
-
Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.Cell. 2006 Aug 25;126(4):755-66. doi: 10.1016/j.cell.2006.06.052. Cell. 2006. PMID: 16923394
-
Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells.Stem Cells. 2008 Apr;26(4):950-9. doi: 10.1634/stemcells.2007-0597. Epub 2008 Jan 10. Stem Cells. 2008. PMID: 18192237
-
Diurnal variation of circulating human myeloid progenitor cells.Exp Hematol. 1980 Aug;8(7):954-60. Exp Hematol. 1980. PMID: 16398029
-
A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy.Trends Immunol. 2009 May;30(5):193-200. doi: 10.1016/j.it.2009.03.001. Epub 2009 Apr 7. Trends Immunol. 2009. PMID: 19356980 Review.
-
Breaking the silence: three bHLH proteins direct cell-fate decisions during stomatal development.Bioessays. 2007 Sep;29(9):861-70. doi: 10.1002/bies.20625. Bioessays. 2007. PMID: 17691100 Review.
Cited by
-
Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility.PLoS Comput Biol. 2009 Jan;5(1):e1000268. doi: 10.1371/journal.pcbi.1000268. Epub 2009 Jan 23. PLoS Comput Biol. 2009. PMID: 19165316 Free PMC article.
-
Spatial epigenetic control of mono- and bistable gene expression.PLoS Biol. 2010 Mar 16;8(3):e1000332. doi: 10.1371/journal.pbio.1000332. PLoS Biol. 2010. PMID: 20305717 Free PMC article.
-
PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis.J Cell Mol Med. 2009 Nov-Dec;13(11-12):4349-63. doi: 10.1111/j.1582-4934.2009.00757.x. Epub 2009 Apr 6. J Cell Mol Med. 2009. PMID: 19382896 Free PMC article. Review.
-
Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch.Biophys J. 2008 Aug;95(4):1575-89. doi: 10.1529/biophysj.107.120600. Epub 2008 May 9. Biophys J. 2008. PMID: 18469073 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources