[Pentobarbital interaction with the GABA-activated ion channels of the neurons in the rat cerebellum]
[Article in
Russian]
- PMID: 1692396
Item in Clipboard
[Pentobarbital interaction with the GABA-activated ion channels of the neurons in the rat cerebellum]
[Article in
Russian]
Neirofiziologiia.
1990.
Abstract
GABA and barbiturate-activated currents of isolated single neurons in the rat cerebellum were studied by means of the concentration clamp, voltage clamp and intracellular perfusion methods. The dissociation constant (Kd) was 3 +/- 0.8.10(-5) M. Pentobarbital potentiated the GABA-induced conduction of isolated neurons. The dose-effect for GABA shifted along the abscissa axes. Optimal concentrations which potentiated the GABA effect were within 10(-6)-10(-4) M. The pentobarbital concentrations above 5.10(-4) M without GABA activated the Cl conductance. The short-time conductance during fast pentobarbital washing off was found to increase.
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