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Comparative Study
. 2006 Aug;70(8):2013-7.
doi: 10.1271/bbb.60260.

Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model

Noritoshi Takahashi  1 , Haruki Kitazawa, Noriyuki Iwabuchi, Jin-Zhong Xiao, Kazuhiro Miyaji, Keiji Iwatsuki, Tadao Saito
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Free article
Comparative Study

Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model

Noritoshi Takahashi et al. Biosci Biotechnol Biochem. 2006 Aug.
Free article

Abstract

We have reported the antiallergic activities of the immunostimulatory oligodeoxynucleotide (ODN) BL07S, identified from genomic DNA of Bifidobacterium longum BB536 from in vitro and in vivo studies. The present study evaluated the efficiency of ODN BL07S in preventing allergic responses by oral administration. Oral administration of BL07S suppressed serum ovalbumin (OVA)-specific immunoglobulin (Ig) E levels and improved the OVA-specific IgG2a/IgG1 ratio. ODN BL07S increased Th1 cytokine and decreased Th2 cytokine production in splenocytes. These results suggest that immunostimulatory ODNs are potentially associated with the antiallergic effects of probiotics.

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