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. 2006 Oct;13(10):1177-9.
doi: 10.1128/CVI.00257-06. Epub 2006 Aug 23.

Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media

Birgit Simell  1 , Teija Jaakkola, Mika Lahdenkari, David Briles, Susan Hollingshead, Terhi M Kilpi, Helena Käyhty
Affiliations

Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media

Birgit Simell et al. Clin Vaccine Immunol. 2006 Oct.

Abstract

Pneumococcal neuraminidase, NanA, is a pneumococcal vaccine candidate. Prior culture-confirmed pneumococcal contacts were shown to induce serum anti-NanA antibodies during the first 2 years of life. The antibody concentrations at neither 12 nor 18 months were significantly associated with the risk of subsequent pneumococcal carriage or acute otitis media.

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Figures

FIG. 1.
FIG. 1.
Development of serum anti-NanA IgG antibodies during the first 24 months of life in pnc− and pnc+ children. Numbers in parentheses indicate the numbers of samples analyzed at each age point. During the follow-up, the proportion of pnc+ children increased, while the proportion of pnc− children decreased. Geometric mean concentrations with 95% confidence intervals are given. *, P < 0.001 for pnc+ versus pnc− children (Student's t test).
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