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Meta-Analysis
. 2006;85(9):1066-79.
doi: 10.1080/00016340600697306.

Geographical variation in relationships between parental body size and offspring phenotype at birth

Sam Leary  1 , Caroline Fall, Clive Osmond, Hermione Lovel, Doris Campbell, Johan Eriksson, Terrence Forrester, Keith Godfrey, Jacqui Hill, Mi Jie, Catherine Law, Rachel Newby, Sian Robinson, Chittaranjan Yajnik
Affiliations
Meta-Analysis

Geographical variation in relationships between parental body size and offspring phenotype at birth

Sam Leary et al. Acta Obstet Gynecol Scand. 2006.

Abstract

Background: Size and body proportions at birth are partly determined by maternal body composition, but most studies of mother-baby relationships have only considered the effects of maternal height and weight on offspring birth weight, and few have examined the size of effects. Paternal size and body composition also play a role, primarily through the fetal genome, although few studies have investigated relationships with neonatal phenotype.

Methods: Data from the UK, Finland, India, Sri Lanka, China, DR Congo, Nigeria and Jamaica were used to investigate the effects of maternal measures (derived at 30 weeks' gestation, n=16,418), and also paternal size (n=3,733) on neonatal phenotype, for singleton, live-born, term births.

Results: After accounting for variation in maternal size and shape across populations, differences in neonatal phenotype were markedly reduced. Mother-baby relationships were similar across populations, although some were stronger in developing countries. Maternal height was generally the strongest predictor of neonatal length, maternal head circumference of neonatal head and maternal skinfold thickness of neonatal skinfolds. Relationships with maternal arm muscle area were generally weak. Effects of paternal height and body mass index were weaker than the equivalent maternal measurements in most studies.

Conclusions: Differences in maternal body composition account for a large part of the geographical variation in neonatal phenotype. The size of the effects of all maternal measures on neonatal phenotype suggests that nutrition at every stage of the mother's life cycle may influence fetal growth. Further research is needed into father-baby relationships and the genetic mechanisms that influence fetal growth.

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Figures

Figure 1
Figure 1
Maternal 30-week BMI effect on neonatal birthweight, by study
Figure 2
Figure 2
Study effects on neonatal birthweight, before and after adjusting for maternal height and 30-week BMI
See this image and copyright information in PMC

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References

    1. Barker DJP. Mothers, babies and health in later life. Churchill Livingstone; Edinburgh: 1998.
    1. World Health Organisation Maternal anthropometry and pregnancy outcomes. Bull World Health Organ. 1995:S73.
    1. Kramer MS. Determinants of low birth weight: methodological assessment and meta-analysis. Bull World Health Organ. 1987;65:663–737. - PMC - PubMed
    1. Godfrey KM, Hales CN, Osmond C, Barker DJ, Taylor KP. Relation of cord plasma concentrations of proinsulin, 32-33 split proinsulin, insulin and C-peptide to placental weight, body size and body proportions at birth. Early Hum Dev. 1996;46:129–40. - PubMed
    1. Godfrey KM, Matthews N, Glazier J, Jackson A, Wilman C, Sibley CP. Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy. J Clin Endocrinol Metab. 1998;83:3320–6. - PubMed

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