doi: 10.1007/BF02253712.
Neuropeptide substance P improves water maze performance in aged rats
Affiliations
- PMID: 1693002
- DOI: 10.1007/BF02253712
Item in Clipboard
Neuropeptide substance P improves water maze performance in aged rats
Psychopharmacology (Berl).
1990.
Abstract
The effects of the peripherally administered neuropeptide substance P (SP) on spatial learning capacities were investigated in 27-month-old rats using a water-maze task. Old rats were injected intraperitoneally once daily for 6 days with 50 or 250 micrograms/kg SP or vehicle 30 min prior to acquisition trials. Improvement in maze performance was observed following injections of 250 micrograms/kg SP only. Furthermore, vehicle-treated old rats showed significantly poorer acquisition rates than vehicle-treated 12-week-old rats. Thus, the improvement in performance after the 250 micrograms/kg dose of SP can be interpreted in terms of a compensation of performance deficit in the old rats.
Similar articles
-
Chronic administration of neurokinin SP improves maze performance in aged Rattus norvegicus.Behav Neural Biol. 1994 Sep;62(2):110-20. doi: 10.1016/s0163-1047(05)80032-9. Behav Neural Biol. 1994. PMID: 7527633
-
DAU 6215, a novel 5-HT3 receptor antagonist, improves performance in the aged rat in the Morris water maze task.Neurobiol Aging. 1993 Nov-Dec;14(6):561-4. doi: 10.1016/0197-4580(93)90039-e. Neurobiol Aging. 1993. PMID: 8295658
-
Effects of chronic substance P treatment and intracranial fetal grafts on learning after hippocampal kainic acid lesions.Peptides. 1996;17(2):275-85. doi: 10.1016/0196-9781(95)02105-1. Peptides. 1996. PMID: 8801534
-
Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task.Pharmacol Biochem Behav. 1994 Jan;47(1):95-9. doi: 10.1016/0091-3057(94)90116-3. Pharmacol Biochem Behav. 1994. PMID: 8115433
-
The effects of noradrenergic neurotoxin, DSP-4, on the performance of young and aged rats in spatial navigation task.Brain Res. 1991 Nov 1;563(1-2):297-302. doi: 10.1016/0006-8993(91)91550-k. Brain Res. 1991. PMID: 1786544
Cited by
-
Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels.PLoS One. 2013 Nov 12;8(11):e78036. doi: 10.1371/journal.pone.0078036. eCollection 2013. PLoS One. 2013. PMID: 24265678 Free PMC article.
-
Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity.Psychopharmacology (Berl). 1993;112(2-3):147-62. doi: 10.1007/BF02244906. Psychopharmacology (Berl). 1993. PMID: 7532865 Review.
-
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain.Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):355-62. doi: 10.1007/BF00168640. Naunyn Schmiedebergs Arch Pharmacol. 1996. PMID: 8692293
-
S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies.CNS Drug Rev. 2002 Spring;8(1):31-52. doi: 10.1111/j.1527-3458.2002.tb00214.x. CNS Drug Rev. 2002. PMID: 12070525 Free PMC article. Review.
-
Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of age-related cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor.Learn Mem. 2000 May-Jun;7(3):159-69. doi: 10.1101/lm.7.3.159. Learn Mem. 2000. PMID: 10837505 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
