doi: 10.1016/j.phytochem.2006.06.033.
Epub 2006 Aug 22.
An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum
Affiliations
- PMID: 16930645
- DOI: 10.1016/j.phytochem.2006.06.033
Item in Clipboard
An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum
Phytochemistry.
2006 Oct.
Abstract
A fusidane triterpene, 16-deacetoxy-7-beta-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all (1)H and (13)C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 microg/ml.
Similar articles
-
Protostane and fusidane triterpenes: a mini-review.Molecules. 2013 Apr 5;18(4):4054-80. doi: 10.3390/molecules18044054. Molecules. 2013. PMID: 23563857 Free PMC article. Review.
-
In-vitro activity of quinupristin/dalfopristin, levofloxacin and moxifloxacin against fusidic acid and rifampicin-resistant strains of methicillin-resistant Staphylococcus aureus (MRSA) from Malaysian hospitals.Med J Malaysia. 2005 Oct;60(4):411-5. Med J Malaysia. 2005. PMID: 16570701
-
A novel antibacterial iridoid and triterpene from Caiophora coronata.J Nat Prod. 2003 Dec;66(12):1628-31. doi: 10.1021/np030314a. J Nat Prod. 2003. PMID: 14695811
-
Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus.Org Lett. 2009 Mar 19;11(6):1241-4. doi: 10.1021/ol802696a. Org Lett. 2009. PMID: 19216560
-
Dumb and dumber--the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus.Clin Infect Dis. 2006 Feb 1;42(3):394-400. doi: 10.1086/499365. Epub 2005 Dec 15. Clin Infect Dis. 2006. PMID: 16392088 Review.
Cited by
-
Microbial Oxidation of the Fusidic Acid Side Chain by Cunninghamella echinulata.Molecules. 2018 Apr 21;23(4):970. doi: 10.3390/molecules23040970. Molecules. 2018. PMID: 29690500 Free PMC article.
-
Protostane and fusidane triterpenes: a mini-review.Molecules. 2013 Apr 5;18(4):4054-80. doi: 10.3390/molecules18044054. Molecules. 2013. PMID: 23563857 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
