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. 2006 Oct;67(19):2110-4.
doi: 10.1016/j.phytochem.2006.06.033. Epub 2006 Aug 22.

An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans  1 , John N Hedger, David Brayford, Michael Stavri, Eileen Smith, Gemma O'Donnell, Alexander I Gray, Gareth W Griffith, Simon Gibbons
Affiliations

An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans et al. Phytochemistry. 2006 Oct.

Abstract

A fusidane triterpene, 16-deacetoxy-7-beta-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all (1)H and (13)C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 microg/ml.

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