Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Aug;2(8):e91.
doi: 10.1371/journal.ppat.0020091.

The SIV surface spike imaged by electron tomography: one leg or three?

Sriram Subramaniam  1
Affiliations
Comment

The SIV surface spike imaged by electron tomography: one leg or three?

Sriram Subramaniam. PLoS Pathog. 2006 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests. The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Principle of 3-D Imaging Using Electron Tomography
(A) Schematic illustrating the principle of data collection for electron tomography by tilting specimens relative to the electron beam. (B) Rendering of three “perfect” projection views (at 0°, 35°, and 70°) generated by rotating a vitrified film of ice-embedded molecules relative to the electron beam. The structure shown is that of the oxalate transporter determined at 6.5 Å resolution using electron crystallography [18]. Structure determination by electron tomography involves starting with a set of projection images which are then effectively “smeared” out along their viewing directions to form back-projection profiles. These profiles are combined appropriately to recover the density distribution of the imaged object.
See this image and copyright information in PMC

Comment on

References

    1. Douek DC, Kwong PD, Nabel GJ. The rational design of an AIDS vaccine. Cell. 2006;124:677–681. - PubMed
    1. Kwong PD, Wyatt R, Majeed S, Robinson J, Sweet RW, et al. Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. Structure. 2000;8:1329–1339. - PubMed
    1. Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, et al. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature. 2005;433:834–841. - PubMed
    1. Caffrey M, Cai M, Kaufman J, Stahl SJ, Wingfield PT, et al. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 1998;17:4572–4584. - PMC - PubMed
    1. Zanetti G, Briggs JAG, Grunewald K, Sattentau Q, Fuller SD. Cryo-electron tomographic structure of an Immunodeficiency Virus Envelope complex in situ test. PLoS Pathog. 2006;2(8):e83. - PMC - PubMed

MeSH terms

Substances