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. 2006 Nov 1;16(21):5493-7.
doi: 10.1016/j.bmcl.2006.08.049. Epub 2006 Aug 28.

Epibatidine isomers and analogues: structure-activity relationships

Richard White  1 , John R Malpass, Sandeep Handa, S Richard Baker, Lisa M Broad, Liz Folly, Adrian Mogg
Affiliations

Epibatidine isomers and analogues: structure-activity relationships

Richard White et al. Bioorg Med Chem Lett. .

Abstract

Binding affinities for a range of epibatidine isomers and analogues at the alpha4beta2 and alpha3beta4 nAChR subtypes are reported; compounds having similar N-N distances to epibatidine show similar, high potencies.

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