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Case Reports
. 2007 Jan;81(2):197-9.
doi: 10.1007/s11060-006-9217-y. Epub 2006 Aug 26.

Intrathecal anti-CD20 antibody: an effective and safe treatment for leptomeningeal lymphoma

Giovanni Antonini  1 , Maria Cristina Cox, Enrico Montefusco, Antonella Ferrari, Esmeralda Conte, Stefania Morino, Pamela Latino, Guido Trasimeni, Bruno Monarca
Affiliations
Case Reports

Intrathecal anti-CD20 antibody: an effective and safe treatment for leptomeningeal lymphoma

Giovanni Antonini et al. J Neurooncol. 2007 Jan.

Abstract

A patient with relapsed B cell non-Hodgkin lymphoma (NHL) infiltrating the Central nervous system (CNS) and resistant to chemotherapy was treated with intrathecal Rituximab (IT RTX), administered weekly for eight weeks at increasing doses, from 10 to 40 mg. After the second administration the patient showed significant clinical improvement and Cerebro spinal fluid (CSF) clearance of lymphomatous cells. A MRI scan performed after 30 days from the start of therapy showed full regression of lymphomatous infiltration. This report confirms the efficacy and safety of IT RTX in the treatment of CNS B-cell NHL.

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References

    1. Int J Clin Oncol. 2005 Oct;10(5):357-61 - PubMed
    1. Blood. 2005 Jan 15;105(2):496-502 - PubMed
    1. Haematologica. 2004 Jun;89(6):753-4 - PubMed
    1. Blood. 1999 Oct 1;94(7):2217-24 - PubMed
    1. Ann Intern Med. 1993 Dec 1;119(11):1093-104 - PubMed

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