Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Aug 14;12(30):4819-31.
doi: 10.3748/wjg.v12.i30.4819.

Extraintestinal manifestations and complications in inflammatory bowel diseases

Affiliations
Review

Extraintestinal manifestations and complications in inflammatory bowel diseases

Katja S Rothfuss et al. World J Gastroenterol. .

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) that often involve organs other than those of the gastrointestinal tract. These nonintestinal affections are termed extraintestinal symptoms. Differentiating the true extraintestinal manifestations of inflammatory bowel diseases from secondary extraintestinal complications, caused by malnutrition, chronic inflammation or side effects of therapy, may be difficult. This review concentrates on frequency, clinical presentation and therapeutic implications of extraintestinal symptoms in inflammatory bowel diseases. If possible, extraintestinal manifestations are differentiated from extraintestinal complications. Special attention is given to the more recently described sites of involvement; i.e. thromboembolic events, osteoporosis, pulmonary involvement and affection of the central nervous system.

PubMed Disclaimer

Figures

Figure 1
Figure 1
X-ray thoracic spine demonstrating ankylosing spondylitis (Bechterew's disease) with syndesmophytes/bamboo spine in a patient with CD.
Figure 2
Figure 2
Erythema nodosum in a patient with CD.
Figure 3
Figure 3
Pyoderma gangrenosum in a patient with CD.
Figure 4
Figure 4
Sweet syndrome: papulosquamous exanthema in a patient with UC.
Figure 5
Figure 5
ERC demonstrating primary sclerosing cholangitis in a patient with CD.

References

    1. Bernstein CN, Blanchard JF, Rawsthorne P, Yu N. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. Am J Gastroenterol. 2001;96:1116–1122. - PubMed
    1. Ricart E, Panaccione R, Loftus EV, Tremaine WJ, Harmsen WS, Zinsmeister AR, Sandborn WJ. Autoimmune disorders and extraintestinal manifestations in first-degree familial and sporadic inflammatory bowel disease: a case-control study. Inflamm Bowel Dis. 2004;10:207–214. - PubMed
    1. Bernstein CN, Wajda A, Blanchard JF. The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterology. 2005;129:827–836. - PubMed
    1. Mendoza JL, Lana R, Taxonera C, Alba C, Izquierdo S, Díaz-Rubio M. [Extraintestinal manifestations in inflammatory bowel disease: differences between Crohn's disease and ulcerative colitis] Med Clin (Barc) 2005;125:297–300. - PubMed
    1. Bhagat S, Das KM. A shared and unique peptide in the human colon, eye, and joint detected by a monoclonal antibody. Gastroenterology. 1994;107:103–108. - PubMed

MeSH terms