Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Aug 21;12(31):5017-20.
doi: 10.3748/wjg.v12.i31.5017.

Effects of chronic therapy with non-steroidal antiinflammatory drugs on gastric permeability of sucrose: a study on 71 patients with rheumatoid arthritis

Marta Maino  1 , Nicola Mantovani, Roberta Merli, Giulia Martina Cavestro, Gioacchino Leandro, Lucas Giovanni Cavallaro, Vincenzo Corrente, Veronica Iori, Alberto Pilotto, Angelo Franzè, Francesco Di Mario
Affiliations

Effects of chronic therapy with non-steroidal antiinflammatory drugs on gastric permeability of sucrose: a study on 71 patients with rheumatoid arthritis

Marta Maino et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the gastric permeability after both acute and chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) and to assess the clinical usefulness of sucrose test in detecting and following NSAIDs- induced gastric damage mainly in asymptomatic patients and the efficacy of a single pantoprazole dose in chronic users.

Methods: Seventy-one consecutive patients on chronic therapy with NSAIDs were enrolled in the study and divided into groups A and B (group A receiving 40 mg pantoprazole daily, group B only receiving NSAIDs). Sucrose test was performed at baseline and after 2, 4 and 12 wk, respectively. The symptoms in the upper gastrointestinal tract were recorded.

Results: The patients treated with pantoprazole had sucrose excretion under the limit during the entire follow-up period. The patients without gastroprotection had sucrose excretion above the limit after 2 wk, with an increasing trend in the following weeks (P = 0.000). A number of patients in this group revealed a significantly altered gastric permeability although they were asymptomatic during the follow-up period.

Conclusion: Sucrose test can be proposed as a valid tool for the clinical evaluation of NSAIDs- induced gastric damage in both acute and chronic therapy. This technique helps to identify patients with clinically silent gastric damages. Pantoprazole (40 mg daily) is effective and well tolerated in chronic NSAID users.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Sucrose test in patients of the study. Group A = pantoprazole 40 mg and Group B = no therapy.
Figure 2
Figure 2
Sucrose test in Group B patients accordingly to their symptoms.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Retail & Provider Perspective, National Prescription Audit, 1999-2000. Plymouth, PA: IMS Health; 2000.
    1. Editoriale: Il mercato farmaceutico mondiale nel 2001. Bollettino Informazione sui farmaci. 2001;6:275–277.
    1. Koutsos MI, Shiff SJ, Rigas B. Can nonsteroidal anti-inflammatory drugs be recommended to prevent colon cancer in high risk elderly patients. Drugs Aging. 1995;6:421–425. - PubMed
    1. Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R, Petrelli N, Pipas JM, Karp DD, Loprinzi CL, et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med. 2003;348:883–890. - PubMed
    1. Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, McKeown-Eyssen G, Summers RW, Rothstein R, Burke CA, et al. A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med. 2003;348:891–899. - PubMed