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Clinical Trial
. 2007 May;135(4):583-91.
doi: 10.1017/S0950268806007163. Epub 2006 Aug 29.

Trends in encephalitis-associated deaths in the United States

N Khetsuriani  1 , R C Holman, A C Lamonte-Fowlkes, R M Selik, L J Anderson
Affiliations
Clinical Trial

Trends in encephalitis-associated deaths in the United States

N Khetsuriani et al. Epidemiol Infect. 2007 May.

Abstract

The United States national mortality statistics and HIV/AIDS surveillance data were analysed to determine trends in encephalitis-associated deaths and to assess the impact of HIV infection on those deaths during 1979-1998, a period when ICD-9 codes were used for coding deaths in the United States. A total of 25125 encephalitis deaths were reported; 4779 of them (19%) had concurrent HIV infection. Overall encephalitis death rates remained stable, but they increased for groups where HIV infection was common and declined or remained unchanged for others. For persons without HIV infection, the rates declined in all demographic groups. Encephalitis deaths in HIV-infected persons followed general trends for HIV deaths in the United States. The rates in the HIV-infected population were several hundred- to thousand-fold higher than in the HIV-uninfected population. HIV infection was largely responsible for the lack of overall decline in the considerable mortality associated with encephalitis in the United States during 1979-1998.

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Figures

Fig. 1
Fig. 1
Encephalitis-associated death rates in the general population of the United States by year, 1979–1998. (a) Overall rates and rates of encephalitis deaths with and without concurrent HIV infection; (b), rates by sex; (c), rates by race; (d), rates by age group. All rates except those by age group are age-adjusted.
Fig. 2
Fig. 2
Encephalitis-associated death rates in the HIV-infected and uninfected populations. (a) In populations with and without AIDS, United States, 1984–1998; (b), among total HIV-infected, AIDS, and HIV-uninfected populations in the 25 states conducting confidential name-based HIV/AIDS surveillance, 1994–1998.
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