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. 2006 Sep;169(2):114-20.
doi: 10.1016/j.cancergencyto.2006.03.011.

Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism

Irina Stasevich  1 , Regina Utskevich, Anatoly Kustanovich, Natallia Litvinko, Tatsiana Savitskaya, Svetlana Chernyavskaya, Olga Saharova, Olga Aleinikova
Affiliations

Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism

Irina Stasevich et al. Cancer Genet Cytogenet. 2006 Sep.

Abstract

Using both conventional and molecular cytogenetic methods, we found five new cases of t(10;11)(p12;q23). This translocation represented 28% of all cases of childhood AML treated at our center in 2004, and 63% of AML with rearrangements of 11q23. We describe three mechanisms for the translocation. Different fragments of 11q were involved in four of the five cases. One patient showed a cytogenetically cryptic insertion of 5' part of MLL into the 3' part of MLLT10 in 10p12. The median event-free survival of patients was 8.1 months, and we conclude that the t(10;11)(p12;q23) is associated with unfavorable prognosis in childhood acute myeloid leukemia.

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