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. 2006 Sep;5(17):1925-8.
doi: 10.4161/cc.5.17.3200. Epub 2006 Sep 1.

Topoisomerase II checkpoints: universal mechanisms that regulate mitosis

Duncan J Clarke  1 , Amit C Vas, Catherine A Andrews, Laura A Díaz-Martínez, Juan F Giménez-Abián
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Topoisomerase II checkpoints: universal mechanisms that regulate mitosis

Duncan J Clarke et al. Cell Cycle. 2006 Sep.

Abstract

Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.

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