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. 2006 Aug 30:1:24.
doi: 10.1186/1746-1596-1-24.

Clinical-histopathological correlation in a case of Coats' disease

Bruno F Fernandes  1 , Alexandre N Odashiro, Shawn Maloney, Moyses E Zajdenweber, Andressa G Lopes, Miguel N Burnier Jr
Affiliations

Clinical-histopathological correlation in a case of Coats' disease

Bruno F Fernandes et al. Diagn Pathol. .

Abstract

Background: Coats' disease is a non-hereditary ocular disease, with no systemic manifestation, first described by Coats in 1908. It occurs more commonly in children and has a clear male predominance. Most patients present clinically with unilateral decreased vision, strabismus or leukocoria. The most important differential diagnosis is unilateral retinoblastoma, which occurs in the same age group and has some overlapping clinical manifestations.

Case presentation: A 4 year-old girl presented with a blind and painful right eye. Ocular examination revealed neovascular glaucoma, cataract and posterior synechiae. Although viewing of the fundus was impossible, computed tomography disclosed total exudative retinal detachment in the affected eye. The eye was enucleated and subsequent histopathological evaluation confirmed the diagnosis of Coats' disease.

Conclusion: General pathologists usually do not have the opportunity to receive and study specimens from patients with Coats' disease. Coats' disease is one of the most important differential diagnoses of retinoblastoma. Therefore, it is crucial for the pathologist to be familiar with the histopathological features of the former, and distinguish it from the latter.

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Figures

Figure 1
Figure 1
Clinical photography. Conjunctival hyperemia, mild corneal edema, posterior synechiae and cataract.
Figure 2
Figure 2
Computed Tomography. Total exsudative retinal detachment in the right eye.
Figure 3
Figure 3
Coats' disease: histopathological findings. Total exsudative retinal detachment (H&E).
Figure 4
Figure 4
Coats' disease: histopathological findings. Subretinal fluid with cholesterol clefts and lipid-laden macrophages (H&E. Original magnification × 400).
Figure 5
Figure 5
Coats' disease: histopathological findings. Intraretinal cholesterol deposition triggering a giant cell reaction foreign-body type (H&E. Original magnification × 400).
Figure 6
Figure 6
Coats' disease: histopathological findings. Telangiectasic retinal vessels (PAS. Original magnification × 200).
See this image and copyright information in PMC

References

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