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Randomized Controlled Trial
. 2006 Sep;14(9):803-7.
doi: 10.1097/01.JGP.0000218327.21111.de.

Paroxetine treatment of primary insomnia in older adults

Charles F Reynolds 3rd  1 , Daniel J Buysse, Mark D Miller, Bruce G Pollock, Martica Hall, Sati Mazumdar
Affiliations
Randomized Controlled Trial

Paroxetine treatment of primary insomnia in older adults

Charles F Reynolds 3rd et al. Am J Geriatr Psychiatry. 2006 Sep.

Abstract

Objective: The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults.

Methods: Adults over age 55 with primary insomnia were randomly assigned to six weeks of double-blind treatment with paroxetine (N = 14) or placebo (N = 13). Outcome measures included persistence or resolution of insomnia; weekly diary measures of sleep quality, daytime alertness, and mood; and pre-/postpolysomnographic measures of sleep latency, wake time after sleep onset, and sleep efficiency.

Results: Although weekly diary-based measures showed improved subjective sleep quality, daytime alertness, and mood with paroxetine, the authors observed no effect on sleep efficiency or categorical response rates.

Conclusion: Paroxetine appears to be ineffective for treating primary insomnia in old age.

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