Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Aug 28;174(5):613-4.
doi: 10.1083/jcb.200608014.

When sparks get old

Werner Melzer  1
Affiliations
Comment

When sparks get old

Werner Melzer. J Cell Biol. .

Abstract

Sparks are transient local elevations of Ca ion concentration observed in different types of muscle cells. Such local Ca2+ signals can be provoked in skeletal muscle cells by altering the osmotic pressure of the extracellular solution. In this issue, Weisleder et al. (see p. 639) demonstrate that the Ca2+ response to osmotic stress is substantially altered in aged muscle. The study presents evidence for a link between this finding and a reduced expression of mitsugumin 29 (MG29), a small membrane protein of the sarcoplasmic reticulum (SR).

PubMed Disclaimer

Comment on

References

    1. Beard, N.A., M.G. Casarotto, L. Wei, M. Varsanyi, D.R. Laver, and A.F. Dulhunty. 2005. Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation. Biophys. J. 88:3444–3454. - PMC - PubMed
    1. Dirksen, R.T. 2002. Bi-directional coupling between dihydropyridine receptors and ryanodine receptors. Front. Biosci. 7:d659–d670. - PubMed
    1. Herrmann-Frank, A., and F. Lehmann-Horn. 1996. Regulation of the purified Ca2+ release channel/ryanodine receptor complex of skeletal muscle sarcoplasmic reticulum by luminal calcium. Pflugers Arch. 432:155–157. - PubMed
    1. Kirsch, W.G., D. Uttenweiler, and R.H. Fink. 2001. Spark- and ember-like elementary Ca2+ release events in skinned fibres of adult mammalian skeletal muscle. J. Physiol. 537:379–389. - PMC - PubMed
    1. Klein, M.G., H. Cheng, L.F. Santana, Y.H. Jiang, W.J. Lederer, and M.F. Schneider. 1996. Two mechanisms of quantized calcium release in skeletal muscle. Nature. 379:455–458. - PubMed