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Clinical Trial
. 2007 Mar;82(1):81-3.
doi: 10.1007/s11060-006-9241-y. Epub 2006 Aug 31.

Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

Marc C Chamberlain  1 , Michael J Glantz, Lisa Chalmers, Alixis Van Horn, Andrew E Sloan
Affiliations
Clinical Trial

Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

Marc C Chamberlain et al. J Neurooncol. 2007 Mar.

Abstract

Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.

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