Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 Sep;5(9):2372-9.
doi: 10.1021/pr060206k.

Identification of 14-3-3epsilon substrates from embryonic murine brain

Bryan A Ballif  1 , Zhongwei Cao, Daniel Schwartz, Kermit L Carraway 3rd, Steven P Gygi
Affiliations
Comparative Study

Identification of 14-3-3epsilon substrates from embryonic murine brain

Bryan A Ballif et al. J Proteome Res. 2006 Sep.

Abstract

Mice deficient in 14-3-3epsilon exhibit abnormal neuronal migration and die perinatally. We report here the first large-scale analysis of 14-3-3 interacting partners from primary animal tissue, identifying from embryonic murine brain 163 14-3-3epsilon interacting proteins and 85 phosphorylation sites on these proteins. Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol.

PubMed Disclaimer

Publication types

LinkOut - more resources