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. 1990 Jun;14(3):259-66.
doi: 10.1007/BF00915810.

Lytic, agglutinating, and opsonizing effect of alpha 2-macroglobulin on sheep red blood cells

L Isaac  1 , M Mariano
Affiliations

Lytic, agglutinating, and opsonizing effect of alpha 2-macroglobulin on sheep red blood cells

L Isaac et al. Inflammation. 1990 Jun.

Abstract

Mouse alpha 2-macroglobulin (alpha 2M) induced agglutination and lysis of sheep red blood cells depending on temperature and time of incubation in vitro. When these erythrocytes (E) were treated with a subagglutinanting dose of alpha 2M, they were adhered to and phagocytosed by thioglycollate-elicited and BCG-activated mouse peritoneal macrophages. Phagocytosis was not observed when resident peritoneal macrophages were tested. alpha 2M also was able to dissociate sheep red blood cells previously aggregated by IgM anti-E.

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