Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jun;14(3):259-66.
doi: 10.1007/BF00915810.

Lytic, agglutinating, and opsonizing effect of alpha 2-macroglobulin on sheep red blood cells

L Isaac  1 , M Mariano
Affiliations

Lytic, agglutinating, and opsonizing effect of alpha 2-macroglobulin on sheep red blood cells

L Isaac et al. Inflammation. 1990 Jun.

Abstract

Mouse alpha 2-macroglobulin (alpha 2M) induced agglutination and lysis of sheep red blood cells depending on temperature and time of incubation in vitro. When these erythrocytes (E) were treated with a subagglutinanting dose of alpha 2M, they were adhered to and phagocytosed by thioglycollate-elicited and BCG-activated mouse peritoneal macrophages. Phagocytosis was not observed when resident peritoneal macrophages were tested. alpha 2M also was able to dissociate sheep red blood cells previously aggregated by IgM anti-E.

PubMed Disclaimer

References

    1. Anal Biochem. 1972 Aug;48(2):422-7 - PubMed
    1. J Immunol. 1986 Apr 15;136(8):2792-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Jan;82(1):9-13 - PubMed
    1. J Biol Chem. 1979 Aug 10;254(15):7329-35 - PubMed
    1. J Immunol. 1989 Jan 1;142(1):148-52 - PubMed