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Review
. 2006 Sep;231(8):1283-6.
doi: 10.1177/153537020623100801.

Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents

Julian L Ambrus Sr  1 , Kailash C Chadha, Anwarul Islam, Selina Akhter, Julian L Ambrus Jr
Affiliations
Free article
Review

Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents

Julian L Ambrus Sr et al. Exp Biol Med (Maywood). 2006 Sep.
Free article

Abstract

Many attempts have been made to inhibit viral and neoplastic diseases by targeting the RNA system. The pathophysiologic significance of the microRNA system and the therapeutic potential of its manipulation are discussed. Studies of double-stranded RNA derivatives are reviewed. The therapeutic potential of one of these compounds, polyI:MPC, is emphasized. Studies of other related antiviral and antineoplastic agents are discussed, including 2'-deoxyoligocytidilates and telomerase inhibitors.

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