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. 2006 Sep;54(9):1318-21.
doi: 10.1248/cpb.54.1318.

Major metabolites of zolpidem: expeditious synthesis and mass spectra

Frédérique Klupsch  1 , Raymond Houssin, Luc Humbert, Michel Imbenotte, Jean-Pierre Hénichart, Michel Lhermitte
Affiliations
Free article

Major metabolites of zolpidem: expeditious synthesis and mass spectra

Frédérique Klupsch et al. Chem Pharm Bull (Tokyo). 2006 Sep.
Free article

Abstract

An expeditious route to the two major metabolites of Zolpidem-and readily applicable to the synthesis of the drug-was established via a cyclization reaction between a 2-aminopyridine and a suitable alpha-bromoacetophenone. The structures of the target compounds were confirmed from a 2D (1)H-(15)N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.

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