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Review
. 2006 Jan;11(1):27-39.
doi: 10.1007/s10911-006-9010-8.

Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer

Deepali Sachdev  1 , Douglas Yee
Affiliations
Review

Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer

Deepali Sachdev et al. J Mammary Gland Biol Neoplasia. 2006 Jan.

Abstract

The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.

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